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2019


118. Ethenesulfonyl Fluoride (ESF) and Its Derivatives in SuFEx Click Chemistry and More
Yan-Ping Meng, Shi-Meng Wang, Wan-Yin Fang, Zhi-Zhong Xie, Jing Leng, Hamed Alsulami and Hua-Li Qin, Synthesis, 2019, Accepted Article
DOI:
10.1055/s-0039-1690038
                                  
117. Rh-Catalyzed highly Enantioselective Synthesis of Aliphatic Sulfonyl Fluorides

Balakrishna Moku, Wan-Yin Fang, Jing Leng, Linxian Li, Gao-Feng Zha, K.P. Rakesh and Hua-Li Qin, iScience201921, 695-705.
DOI:10.1016/j.isci.2019.10.051
                                  
116. Making Carbonyls of Amides Nucleophilic and Hydroxyls of Alcohols Electrophilic Mediated by SO2F2 for Synthesis of Esters from Amides

Wan-Yin Fang, Gao-Feng Zha and Hua-Li Qin, Org. Lett. 201921, 8657-8661.
DOI:10.1021/acs.orglett.9b03274
                                     
115. Rh(I)–Diene-Catalyzed Addition of (Hetero)aryl Functionality to 1,3-Dienylsulfonyl Fluorides Achieving Exclusive Regioselectivity and High Enantioselectivity: Generality and Mechanism

Balakrishna Moku, Wan-Yin Fang, Jing Leng, Eric Assen B. Kantchev and Hua-Li Qin, ACS Catal. 2019, 9, 10477-10488.
DOI:10.1021/acscatal.9b03640
                                    
114. SO2F2 mediated cascade dehydrogenative Morita–Baylis–Hillman reaction of the C(sp3)–H of primary alcohols with the C(sp2)–H of electron-deficient olefins for the assembly of allylic alcohols

Ying Jiang, Njud S. Alharbi, Bing Sun and  Hua-Li Qin, RSC Advances20199, 29784-29787.
DOI:10.1039/C9RA05346H
                                  
113. Applications of Sulfuryl Fluoride (SO2F2) for Chemical Transformations
Ravindar Lekkala, Revathi Lekkala, Balakrishna Moku, K. P. Rakesh and Hua-Li Qin, Organic Chemistry Frontiers2019, 6, 3490-3516.
DOI:10.1039/C9QO00747D
                                  
112. Construction of α‐(Hetero)aryl Ethenesulfonyl Fluorides for SuFEx Click Chemistry
Jing Leng, Njud S. Alharbi and Hua-Li Qin, European Journal of Organic Chemistry2019, 6101-6105.
DOI:10.1002/ejoc.201901106
                           
111. Installation of -SO2F groups onto primary amides
Jing Liu, Shi-Meng Wang, Njud S. Alharbi and Hua-Li Qin, Beilstein Journal of Organic Chemistry2019, 15, 1907-1912.
DOI:10.3762/bjoc.15.186
                                   
110. Discovery of δ-sultone-fused pyrazoles for treating Alzheimer’s disease: Design, synthesis, biological evaluation and SAR studies
Yingying Xu, Ziwen Zhang, Xia Jiang, Xing Chen, Zhuo Wang, Hamed Alsulami, Hua-Li Qin and Wenjian Tang,  European Journal of Medicinal Chemistry2019181, 111598.
DOI:10.1016/j.ejmech.2019.111598
                                   
109. Stereoselective Construction of Nitrile-Substituted Cyclopropanes from 2-Substituted Ethenesulfonyl Fluorides via carbon-Sulfur Bond Cleavage
Hao Liu, Balakrishna Moku, Fei Li, Jiabing Ran, Jinsong Han, Sihui Long, Gao-Feng Zha and Hua-Li Qin, Advanced Synthesis & Catalysis2019361, 4596-4601.
DOI:10.1002/adsc.201900635
                                   
108. Synthetic routes and structure-activity relationships (SAR) of anti-HIV agents: A key review
Yu-Mei Huang, Njud S. Alharbi, Bing Sun, C. S. Shantharam, K. P. Rakesh and Hua-Li Qin, European Journal of Medicinal Chemistry, 2019, 181, 111566.
DOI:10.1016/j.ejmech.2019.111566
                                       
107. Construction of Esters through Sulfuryl Fluoride (SO2F2) Mediated Dehydrative Coupling of Carboxylic acids with Alcohols at Room Temperature
Shi-Meng Wang, Njud S. Alharbi and Hua-Li Qin, Synthesis, 2019, 51, 3901-3907.
DOI:10.1055/s-0039-1690017
                                          
106. A SO2F2 mediated mild, practical, and gram-scale dehydroxylative transforming primary alcohols to quaternary ammonium salts
Chuang Zhao, Gao-Feng Zha, Wan-Yin Fang, Njud S. Alharbi and Hua-Li Qin, Tetrahedron2019, 75, 4648−4656.
DOI:10.1016/j.tet.2019.07.007
                                        
105. Converting (E)‐(Hetero)arylethanesulfonyl Fluorides to (Z)‐(Hetero)arylethanesulfonyl Fluorides under Light Irradiation
Yu-Mei Huang, Shi-Meng Wang, Jing Leng, Balakrishna Moku, Chuang Zhao, Njud S. Alharbi and Hua-Li Qin, European Journal of Organic Chemistry2019, 4597−4603.
DOI:10.1002/ejoc.201900799
                                      
104. Rh-catalyzed annulative insertion of terminal olefin onto pyridines via a C-H activation strategy using ethenesulfonyl fluoride (ESF) as ethylene provider
Chen Li and Hua-Li Qin, Org. Lett. 2019, 21, 4495-4499.
DOI:10.1021/acs.orglett.9b01364
                                      
103. Radical scavenging and anti-inflammatory activities of (hetero)arylethenesulfonyl fluorides: Synthesisand structure-activity relationship (SAR) and QSAR studies
Ying Jiang, K. P. Rakesh, Njud S. Alharbi, H. K. Vivek, H. M. Manukumar, Y. H. E. Mohammed and Hua-Li Qin, Bioorganic Chemistry, 2019, 89, 103015.
DOI:10.1016/j.bioorg.2019.103015
                                       
102. Facile one-pot synthesis of sulfonyl fluorides from sulfonates or sulfonic acids

Ying Jiang,  Njud S. Alharbi,  Bing Sun  and  Hua-Li Qin, RSC Advances, 2019, 9, 13863-13867.
DOI:10.1039/C9RA02531F
                                         
101. Regioselective installation of fluorosulfate (-OSO2F) functionality into aromatic C(sp2)–H bonds for the construction of para-amino-arylfluorosulfates

Wan-Yin Fang,  Gao feng Zha,  Chuang Zhao  and  Hua-Li Qin, Chem. Commun., 2019, 55, 6273-6276.
DOI:10.1039/C9CC02659B
                                         
100. SO2F2 mediated transforming pyrozolones to pyrazolyl fluorosulfates

Jing Leng  and  Hua-Li Qin, Organic & Biomolecular Chemistry2019, 17, 5001-5008
DOI:10.1039/C9OB00903E
                                        
99. SO2F2-mediated transformation of 2'-hydroxyacetophenones to benzo-oxetes

Revathi Lekkala,  Ravindar Lekkala,  Balakrishna Moku,  K. P. Rakesh and  Hua-Li Qin, Beilstein Journal of Organic Chemistry, 2019, 15, 976-980.
DOI:10.3762/bjoc.15.95
                                        
98. A transition-metal-free one-pot cascade process for transformation of primary alcohols (RCH2OH) to nitriles (RCN) mediated by SO2F2
Ying Jiang, Bing Sun, Wan-Yin Fang, Hua-Li Qin, European Journal of Organic Chemistry2019, 3190-3194.
DOI:10.1002/ejoc.201900478
AdvancedScienceNews
                                        
97. Synthetic Approaches and Pharmaceutical Applications of Chloro-Containing Molecules for Drug Discovery: A Critical Review
Wan-Yin Fang, L. Ravindar, K. P. Rakesh, H. M. Manukumar, C. S. Shantharam, Njud S. Alharbi, and Hua-Li Qin, European Journal of Medicinal Chemistry, 2019, 173117-153.
DOI:10.1016/j.ejmech.2019.03.063
                                        
96. Clickable coupling of carboxylic acids and amines at room temperature mediated by SO2F2: A significant breakthrough for the construction of amides and peptide linkages
Shi-Meng Wang,  Chuang Zhao,  Xu Zhang  and  Hua-Li Qin, Organic & Biomolecular Chemistry, 2019, 17, 4087-4101.
DOI:10.1039/C9OB00699K
            
95. Recent Developments of Radical-Mediated Transformations of Organohalides
Ravindar Lekkala, Revathi Lekkala, Balakrishna Moku, K. P. Rakesh, Hua-Li Qin, European Journal of Organic Chemistry2019 2769-2806.
DOI:10.1002/ejoc.201900098
                                             
94. Cascade Process for Direct Transformation of Aldehydes (RCHO) to Nitriles (RCN) Using Inorganic Reagents NH2OH/Na2CO3/SO2F2 in DMSO (ESI 高被引论文;热点论文)
Wan-Yin Fang and Hua-Li Qin, J. Org. Chem. 2019, 84, 5803-5812.
DOI:10.1021/acs.joc.8b03164
                                              

93. A Simple, Mild and General Oxidation of Alcohols to Aldehydes or Ketones by SO2F2/K2CO3 Using DMSO as Solvent and Oxidant
Gao-Feng Zha  Wanyin Fang  Jing Leng  Huali Qin, Advanced Synthesis & Catalysis, 2019, 361, 2262-2267.
https://doi.org/10.1002/adsc.201900104
                                           
92. 
The Significance of N-Methylpicolinamides in the Development of Anticancer Therapeutics: Synthesis and Structure-Activity Relationship (SAR) Studies
Balakrishna Moku, Lekkala Ravindar, K. P. Rakesh, Hua-Li Qin, Bioorganic Chemistry2019, 86, 513-537
DOI:10.1016/j.bioorg.2019.02.030
                                              
91. Transition-metal-free Regioselective Construction of 1,5-Diaryl-1,2,3-triazoles through Dehydrative Cycloaddition of Alcohols with Arylazides Mediated by SO2F(ESI 高被引论文)
Xu Zhang, K. P. Rakesh and Hua-Li Qin, Chem. Commun., 2019, 55, 2845-2848.
DOI:10.1039/C8CC09693G
                                          

90. SO2F2 mediated dehydrative cross-coupling of alcohols with electron-deficient olefins in DMSO using Pd-catalyst: one-pot transformation of alcohols to 1,3-dienes

Revathi Lekkala,  L. Ravindar,  Balakrishna Moku  and  Hua-Li Qin, Organic Chemistry Frontiers, 20196, 796-800. 
DOI:10.1039/C8QO01388H
                          
89. 2-Azidoethane-1-sulfonylfluoride (ASF), a Versatile Bisclickable Reagent for SuFEx and CuAAC Click Reactions
Xu Zhang, Balakrishna Moku, Jing Leng, K. P. Rakesh and Hua-Li Qin, European Journal of Organic Chemistry2019, 1763-1769.
DOI:10.1002/ejoc.201801825
                                           
88. Innovative nano-carriers in anticancer drug delivery-A comprehensive review
Peng Dong, K. P. Rakesh, H. M. Manukumar, Yasser Hussein Eissa Mohammed, C. S. Karthik, S. Sumathi, P. Mallu and Hua-Li Qin, Bioorganic Chemistry, 2019, 85, 325-336.
DOI: 10.1016/j.bioorg.2019.01.019
                                                
87. Construction of Di(hetero)arylmethanes Through Pd-Catalyzed Direct Dehydroxylative Cross-Coupling Benzylic Alcohols and Aryl Boronic Acids Mediated by Sulfuryl Fluoride (SO2F2) (ESI 高被引论文)
Chuang Zhao, Gao-Feng Zha, Wan-Yin Fang, K. P. Rakesh, and Hua-Li Qin, European Journal of Organic Chemistry, 2019, 1801-1807.
DOI: 10.1002/ejoc.201801888
                                         
86. Pharmaceutical and Medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review (ESI 高被引论文)
Chuang Zhao, K. P. Rakesh, L. Ravidar, Wan-Yin Fang, Hua-Li Qin, European Journal of Medicinal Chemistry, 2019, 162, 679-734.
DOI: 10.1016/j.ejmech.2018.11.017
                                        
85.  Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections (ESI高被引论文)
Gao-Feng Zha, Shi-Meng Wang, K. P. Rakesh, S. N. A. Bukhari, H. M. Manukumar, H. K. Vivek, N. Mallesha and Hua-Li Qin, European Journal of Medicinal Chemistry, 2019162, 364-377
DOI: 10.1016/j.ejmech.2018.11.012
                                        

2018


84. SO2F2 Mediated Oxidative Dehydrogenation and Dehydration of Alcohols to Alkynes
Gao-Feng Zha, Wan-Yin Fang, You-Gui Li, Jing Leng, Xing Chen, Hua-Li Qin, J. Am. Chem. Soc., 2018, 140, 17666.
DOI:
10.1021/jacs.8b10069
Organic Chemistry Portal Abstracts
Organic Chemistry Portal Highlights
             
83. Combating a Master Manipulator: Staphylococcus aureus Immunomodulatory Molecules as Targets for Combinatorial Drug Discovery
Kadalipura P. Rakesh, Manukumar H. Marichannegowda, Shobhith Srivastava, Xing Chen, Sihui Long, Chimatahalli S. Karthik, Putswamappa Mallu, Hua-Li Qin, ACS Comb. Sci., 2018, 20, 681-693.
DOI: 10.1021/acscombsci.8b00088
                           


82. Visible-light initiated aerobic oxidations: a critical review
Xu Zhang, K. P. Rakesh, L. Ravindara, Hua-Li Qin, Green Chem., 2018, 20, 4790-4833 
DOI:10.1039/C8GC02382D
                         

 

81. Multi-targeted dihydrazones as potent biotherapeutics
Chen Li, M. B. Sridhara, K. P. Rakesh, H. K. Vivek, H. M. Manukumar, C. S. Shantharam, Hua-Li Qin, Bioorganic Chemistry, 2018, 81, 389-395
https://doi.org/10.1016/j.bioorg.2018.08.024
                                     
80. 
Aryl fluorosulfate analogues as potent antimicrobial agents: SAR, cytotoxicity and docking studies 
Lekkala Ravindar, S. N. A. Bukhari, K. P. Rakesh, H. M. Manukumar, H. K. Vivek, N. Mallesha, Zhi-Zhong Xie, Hua-Li Qin, Bioorganic Chemistry, 2018, 81, 107-118
https://doi.org/10.1016/j.bioorg.2018.08.001
                  
79. 
Role of BP*C@AgNPs in Bap-dependent multicellular behavior of clinically important methicillin-resistant Staphylococcus aureus (MRSA) biofilm adherence: A key virulence study
Zhang Xu, H. M. Manukumar, K. P. Rakesh, C. S. Karthik, H. S. Ngendra Prasad, Nanjunda Swamy, P. Mallu, Eissa Mohammed Yasser Hunnein, Hua-Li Qin, Microbial Pathogenesis, 2018, 123, 275-284
https://doi.org/10.1016/j.micpath.2018.07.025
                                         
78. 
A Rh-Catalyzed Air and Moisture Tolerable Aldehyde (Ketone)-Directed Fluorosulfonylvinylation of Aryl C(sp2)-H Bonds
Chen Li, Shi-Meng Wang, Hua-Li Qin, Org. Lett.,201820, 4699–4703
DOI: 10.1021/acs.orglett.8b02037
                                            
77. 
A Portal to a Class of Novel Sultones Functionalized Pyridines via an Annulative SuFEx Process Employing Earth Abundant Nickel Catalyst
Xing Chen, Gao feng Zha, Wan-Yin Fang, K. P. Rakesh, Hua-Li Qin, Chem. Commun., 2018, 54, 9011-9014
DOI:10.1039/C8CC04032J
                                         
76. Visible Light Induced C-H Bonds Functionalization: A Critical Review
Lekkala Ravindar, Lekkala Revathi, Wan-Yin Fang, K. P. Rakesh, Hua-Li Qin, Advanced Synthesis & Catalysis2018360, 4652-4698.
https://doi.org/10.1002/adsc.201800736
                                            
75. Vision for medicine: Staphylococcus aureus biofilm war and unlocking key's for anti-biofilm drug development

H. M. Manukumar, K. P. Rakesh, C. S. Karthik, P. Mallu, Hua-Li Qin, M. Yasser Hussein Eissa, Microbial Pathogenesis, 2018, 123, 339-347
https://doi.org/10.1016/j.micpath.2018.07.002

                                    

74. Synthesis and biological evaluation of new tetramethylpyrazine based chalcone derivatives as potential anti-Alzheimer agents
Meng Wang, Hua-Li Qin, Jing Leng, Ameeduz zafar, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja, Muhammad Ajaz Hussain, Syed Nasir Abbas Bukhari, Chemical Biology & Drug Design201892, 1859-1866
https://doi.org/10.1111/cbdd.13355
                               
73. 
Rh-Catalyzed Carboxylates Directed C-H Activation for Synthesis of ortho-Carboxylic 2-Arylethenesulfonyl Fluorides: Access to Unique Electrophiles for SuFEx Click Chemistry
Shi-Meng Wang, Balakrishna Moku, Jing Leng, Hua-Li Qin, European Journal of Organic Chemistry, 2018, 32, 4407-4410
https://doi.org/10.1002/ejoc.201800762
                                 
72. 
Multi-targetable chalcone analogues to treat deadly Alzheimer’s disease: current view and upcoming advice
Xu Zhang, K. P. Rakesh, S. N. A. Bukhari, Moku Balakrishna, H. M. Manukumar, Hua-Li Qin, Bioorganic Chemistry, 201880, 86-93
https://doi.org/10.1016/j.bioorg.2018.06.009
                             

71. 
Master mechanisms of Staphylococcus aureus: consider its excellent protective mechanisms hindering vaccine development
Xu Zhang, Manukumar H. Marichannegowda, Kadalipura P. Rakesh, Hua-Li Qin, Microbiological Research2018, 212, 59-66
https://doi.org/10.1016/j.micres.2018.05.002
                                  

70. Pd-Catalyzed One-Pot Dehydroxylative Coupling of Phenols with K4[Fe(CN)6] Mediated by SO2F2:A Practical Method for Direct Converting Phenols to Aryl nitriles
Chuang Zhao, Wan-Yin Fang, K. P. Rakesh, Hua-Li Qin, Org. Chem. Front., 2018, 5, 1835-1839
DOI:10.1039/C8QO00295A
Organic Chemistry Portal Highlights
                               

69. 1-Bromoethene-1-Sulfonyl Fluoride (1-Br-ESF), a New SuFEx Clickable Reagent, and the Application for Regioselective Construction of 5-Sulfonylfluoro Isoxazoles
Jing Leng, Hua-Li Qin, Chem. Commun., 2018, 54, 4477-4480
DOI:10.1039/C8CC00986D
                                       


68. Development of piperazine-1-carbothioamide chitosan silver nanoparticles (P1C-Tit*CAgNPs) as a promising anti-inflammatory candidate: a molecular docking validation

C. S. Karthik, H. M. Manukumar, S. Sandeep, B. L. Sudarshan, S. Nagashree, L. Mallesha, K. P. Rakesh, K. R. Sanjay, P. Mallu, Hua-Li Qin, Med. Chem. Commun., 2018, 9, 713-724
DOI:10.1039/C7MD00628D 
                                 

67. Arylnaphthalene lactone analogues: synthesis and development as excellent biological candidates for future drug discovery
Chuang Zhao, K. P. Rakesh, Saira Mumtaz, Balakrishna Moku, Abdullah M. Asiri, Hadi M. Marwani, H. M. Manukumar, Hua-Li Qin, RSC Adv., 20188, 9487-9502 
DOI:10.1039/C7RA13754K
                                           


66. 
Carbonyl–olefin metathesis: a key review
Lekkala Ravindar, Revathi Lekkala, K. P. Rakesh, Abdullah M. Asiri, Hadi M. Marwani, Hua-Li Qin, Org. Chem. Front., 20185, 1381-1391
DOI:10.1039/C7QO01037K
                              
65. 
Rhodium(III)-catalyzed Oxidative Coupling of N-Methoxybenzamides and Ethenesulfonyl fluoride: a C–H Bond Activation Strategy for the Preparation of 2-Aryl ethenesulfonyl fluorides and Sulfonyl fluoride Substituted γ-Lactams
Shi-Meng Wang, Chen Li, Jing Leng, Syed Nasir Abbas Bukhari, Hua-Li Qin, Org. Chem. Front., 2018, 5, 1411-1415
DOI:10.1039/C7QO01128H
                
64. Promising bactericidal approach of dihydrazone analogues against bio-film forming Gram-negative bacteria and molecular mechanistic studies
K. P. Rakesh, H. K. Vivek, H. M. Manukumar, C. S. Shantharam, S. N. A. Bukhari, Hua-Li Qin, M. B. Sridhara, RSC Adv., 20188, 5473-5483 
DOI:10.1039/C7RA13661G
                                    

63. Pd-catalyzed one-pot dehydroxylative coupling phenols and amines under carbon monoxide atmosphere: a chemical specific discrimination for arylcarboxylic amides synthesis
Wan-Yin Fang, Yu-Mei Huang, Jing Leng, Hua-Li Qin, Asian Journal of Organic Chemistry20187, 751-756
DOI: 10.1002/ajoc.201800037
                                 

62. 
DFT modelling of a diphosphane-N-heterocyclic carbene-Rh(I) pincer complex rearrangement: A computational evaluation of the electronic effects in C-P bond activation
Hua-Li Qin, Jing Leng, Wenqin Zhang, Eric Assen Bonev Kantchev, Dalton Transactions, 2018, 47, 2662 - 2669
DOI:10.1039/C7DT04759B
                                       
61. 
Synthesis and Chemical Transformations of Fluorosulfates (ESI 高被引论文)
Lekkala Revathi, Lekkala Ravindar, Jing Leng, Kadalipura Puttaswamy Rakesh, Hua-Li Qin, Asian Journal of Organic Chemistry20187, 662-682
DOI: 10.1002/ajoc.201700591
                                             

60. Synthesis of novel benzodioxane midst piperazine moiety decorated chitosan silver nanoparticle against biohazard pathogens and as potential anti-inflammatory candidate: A molecular docking studies
C.S. Karthik, H.M. Manukumar, A.P. Ananda, S. Nagashree, K.P. Rakesh, L. Mallesha, Hua-Li Qin, S. Umesha, P. Mallu, N.B. Krishnamurthy, International Journal of Biological Macromolecules2018108, 489-502
https://doi.org/10.1016/j.ijbiomac.2017.12.045




59. Amino acids/Peptides Conjugated Heterocycles: A Tool for the Recent Development of Novel Therapeutic Agents
Meng Wang, K.P. Rakesh, Jing Leng, Wan-Yin Fang, L. Ravindar, D. Channe Gowda, Hua-Li Qin, Bioorganic Chemistry, 201876, 113-129
https://doi.org/10.1016/j.bioorg.2017.11.007
                                 
58. Recent developments on phenstatins as potent antimitotic agents
Xing Chen, Shi-Meng Wang, Gajjela Bharath Kumar, Grant A  L  Bare, Jing Leng, Syed Nasir Abbas Bukhari, Hua-Li Qin, Current Medicinal Chemistry201825, 1627-1649
DOI : 10.2174/0929867324666171106162048

                                        

57. Podophyllotoxin derivatives as an excellent anticancer aspirant for future chemotherapy: A key current imminent needs
Xu Zhang, K.P. Rakesh, C.S. Shantharam, H.M. Manukumar, A.M. Asiri, H.M. Marwani, Hua-Li Qin, Bioorganic & Medicinal Chemistry2018, 26, 340-355
https://doi.org/10.1016/j.bmc.2017.11.026
                                            
56. Recent Development of Sulfonyl or Sulfonamide Hybrids as Potential Anticancer Agents: A Key Review
Rakesh K P, Shi-Meng Wang, Leng Jing, L Ravindar, Abdullah M Asiri, Hadi M Marwani, Hua-Li Qin, Anti-Cancer Agents in Medicinal Chemistry201818, 488-505
DOI : 10.2174/1871520617666171103140749
                                  

2017


55. Emerging trends in therapeutic algorithm of chronic wound healers: Recent advances in drug delivery systems, concepts-to-clinical application, and future prospects
Mei Shao, Zahid Hussain, Hnin Ei Thu, Shahzeb Khan, Marcel de Matas, Victoria Silkstone, Hua-Li Qin, Syed Nasir Abbas Bukhari, Critical Reviews™ in Therapeutic Drug Carrier Systems, 2017, 34, 387-452
DOI: 10.1615/CritRevTherDrugCarrierSyst.2017016957
                                               

54. Synthesis of a Class of Fused δ-Sultone Heterocycles via DBU-Catalyzed Direct Annulative SuFEx Click of Ethenesulfonyl Fluorides and Pyrazolones or 1, 3-Dicarbonyl Compounds
Xing Chen, Gao-Feng Zha, Grant Bare, Jing Leng, Shi-Meng Wang, Hua-Li Qin, Advanced Synthesis & Catalysis, 2017, 359, 3254 – 3260
DOI: 10.1002/adsc.201700887
                         

53. Gram-scale Synthesis of β-(Hetero) arylethenesulfonyl Fluorides via a Pd (OAc)2 (cat.)/DDQ or AgNO3 Mediated Oxidative Heck Process
Gao-Feng Zha, Grant Bare, Jing Leng, Zhen-peng Shang, Zhixiong Luo, Hua-Li Qin, Advanced Synthesis & Catalysis, 2017, 359, 3237-3242
DOI: 10.1002/adsc.201700688
                    
52. SO2F2 Mediated One-Pot Synthesis of Arylcarboxylic Acids and Esters from Phenols via a Pd-Catalyzed Carbon Monoxide Insertion
Wan-Yin Fang, Jing Leng, Hua-Li Qin, Chemistry–An Asian Journal, 2017, 12, 2323 -2331
DOI: 10.1002/asia.201700891
                           

51. Characterization of the RhI/dppe-Catalyzed Ring Expansion of 2-Alkyl-Benzocyclobutenones by DFT Calculations
Hua-Li Qin, Chuang Zhao, Jing Leng, Eric Assen B Kantchev, Chemistry-A European Journal, 201723, 15997-16003
DOI: 10.1002/chem.201703096
                                                 

50. Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance
Gao-Feng Zha, Hua-Li Qin, Bahaa GM Youssif, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja, Ahmed H Abdelazeem, Syed Nasir Abbas Bukhari, European Journal of Medicinal Chemistry, 2017135, 34-48
https://doi.org/10.1016/j.ejmech.2017.04.025
                                         

49. Synthesis, SAR and molecular docking studies of benzo [d] thiazole-hydrazones as potential antibacterial and antifungal agents
Gao-Feng Zha, Jing Leng, N Darshini, T Shubhavathi, HK Vivek, Abdullah M Asiri, Hadi M Marwani, KP Rakesh, N Mallesha, Hua-Li Qin, Bioorganic & Medicinal Chemistry Letters, 2017, 27, 3148-3155
https://doi.org/10.1016/j.bmcl.2017.05.032
                                           

48. A facile and mild Pd-catalyzed one-pot process for direct hydrodeoxygenation (HDO) phenols to arenes through a ArOSO2 F intermediates transformation
Xiao-Yan Wang, Jing Leng, Shi-Meng Wang, Abdullah M Asiri, Hadi M Marwani, Hua-Li Qin, Tetrahedron Letters, 2017, 58, 2340-2343
https://doi.org/10.1016/j.tetlet.2017.04.070
                                                      

47. Chemoselective synthesis of diaryl disulfides via a visible light-mediated coupling of arenediazonium tetrafluoroborates and CS2
Jing Leng, Shi-Meng Wang, Hua-Li Qin, Beilstein Journal of Organic Chemistry, 201713, 903-909
DOI:10.3762/bjoc.13.91
                                    

46. Palladium-Catalyzed Fluorosulfonylvinylation of Organic Iodides
Gao-Feng Zha, Qinheng Zheng, Jing Leng, Peng Wu, Hua-Li Qin, K Barry Sharpless, Angewandte Chemie ,2017, 129, 4927-4930
DOI: 10.1002/ange.201701162
                                  

45. Development of combretastatins as potent tubulin polymerization inhibitors
Syed Nasir Abbas Bukhari, Gajjela Bharath Kumar, Hrishikesh Mohan Revankar, Hua-Li Qin, Bioorganic Chemistry, 2017, 72, 130-147
https://doi.org/10.1016/j.bioorg.2017.04.007
                                            

44. Synthesis of new arylisoxazole–oxindole conjugates as potent antiproliferative agents
Gajjela Bharath Kumar, Syed Nasir Abbas Bukhari, Hua-Li Qin, Chemical biology & drug design, 2017, 89, 634-638
DOI: 10.1111/cbdd.12884
                                                                                  

43. Synthesis and mechanistic studies of curcumin analog-based oximes as potential anticancer agents
Hua-Li Qin, Jing Leng, Bahaa GM Youssif, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja, Muhammad Ajaz Hussain, Zahid Hussain, Syeda Naveed Kazmi, Syed Nasir Abbas Bukhari, Chemical Biology & Drug Design, 2017, 90, 443-449
DOI: 10.1111/cbdd.12964
                                              

42. Bulky Phosphane Ligand for Monoselective Ruthenium-Catalyzed, Directed C–H Arylation with Challenging Aryl Chlorides
You-Gui Li, Zhen-Yu Wang, Ya-Ling Zou, Chau-Ming So, Fuk-Yee Kwong, Hua-Li Qin, Eric Assen B Kantchev, Synlett, 2017, 28, 499-503
DOI: 10.1055/s-0036-1588635
                     

41. Coumarins Scaffolds as COX Inhibitors
Hrishikesh Mohan Revankar, Syed Nasir Abbas Bukhari, Gajjela Bharath Kumar, Hua-Li Qin, Bioorganic Chemistry, 2017, 71, 146-159
https://doi.org/10.1016/j.bioorg.2017.02.001
                         

40. Novel TC@ AgNPs mediated biocidal mechanism against biofilm associated methicillin-resistant Staphylococcus aureus (Bap-MRSA) 090, cytotoxicity and its molecular docking studies
HM Manukumar, B Chandrasekhar, KP Rakesh, AP Anand, M Nandhini, Lalitha Pottail, Sundaravadivelu Sumathi, Hua-Li Qin, S Umesha, Med Chem Comm2017, 8, 2181-2194
DOI: 10.1039/C7MD00486A
                                                                  

39. Benzisoxazole: a privileged scaffold for medicinal chemistry
KP Rakesh, CS Shantharam, MB Sridhara, HM Manukumar, Hua-Li Qin, Med Chem Comm2017, 8, 2023-2039
DOI: 10.1039/C7MD00449D
                                                                                       

38. Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents
Xing Chen, Jing Leng, KP Rakesh, N Darshini, T Shubhavathi, HK Vivek, N Mallesha, Hua-Li Qin, Med Chem Comm, 20178, 1706-1719
DOI: 10.1039/C7MD00209B 
                                              

37. Synthesis of benzo [d] thiazole-hydrazone analogues: molecular docking and SAR studies of potential H+/K+ ATPase inhibitors and anti-inflammatory agents
Shi-Meng Wang, Gao-Feng Zha, KP Rakesh, N Darshini, T Shubhavathi, HK Vivek, N Mallesha, Hua-Li Qin, Med Chem Commun , 2017, 8, 1173-1189
DOI: 10.1039/c7md00111h
                                                     

 36. Cooperativity of axial and centre chirality in the biaryl disulfoxide/Rh (I)-catalysed asymmetric 1, 4-addition of arylboronic aids to 2-cyclohexenone: a DFT study
Gao-Feng Zha, Hua-Li Qin, Eric Assen B Kantchev, Organic & Biomolecular Chemistry2017, 15, 2226-2233 
DOI: 10.1039/C6OB02651F 
                                           

2016


35. [Ru (bpy)3] Cl2-catalyzed aerobic oxidative cleavage β-diketones to carboxylic acids under visible light irradiation
Xiao-Yan Wang, Zhen-Peng Shang, Gao-Feng Zha, Xiao-Qing Chen, Syed Nasir Abbas Bukhari, Hua-Li Qin, Tetrahedron Letters, 2016, 57, 5628-5631
https://doi.org/10.1016/j.tetlet.2016.11.002
                                               

34. Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease
Jing Leng, Hua‐Li Qin, Kaicheng Zhu, Ibrahim Jantan, Muhammad Ajaz Hussain, Muhammad Sher, Muhammad Wahab Amjad, Muhammad Naeem‐ul‐Hassan, Waqas Ahmad, Syed Nasir Abbas Bukhari, Chemical biology & drug design2016, 88, 889-898
DOI: 10.1111/cbdd.12822
                                                  

33. Pd-catalyzed Suzuki–Miyaura cross-coupling of [Ph2SR][OTf] with arylboronic acids
Xiao-Yan Wang, Hai-Xia Song, Shi-Meng Wang, Jing Yang, Hua-Li Qin, Xin Jiang, Cheng-Pan Zhang, Tetrahedron, 2016, 72, 7606-7612
https://doi.org/10.1016/j.tet.2016.10.018
                                
                               

32. A Heck-Matsuda Process for the Synthesis of β-Arylethenesulfonyl Fluorides: Selectively Addressable Bis-electrophiles for SuFEx Click Chemistry
Hua-Li Qin, Qinheng Zheng, Grant AL Bare, Peng Wu, K Barry Sharpless, Angewandte Chemie2016128, 14361-14364
DOI: 10.1002/ange.201608807
                                 

31. Drug nanocarrier, the future of atopic diseases: Advanced drug delivery systems and smart management of disease
Mei Shao, Zahid Hussain, Hnin Ei Thu, Shahzeb Khan, Haliza Katas, Tarek A Ahmed, Minaketan Tripathy, Jing Leng, Hua-Li Qin, Syed Nasir Abbas Bukhari, Colloids and Surfaces B: Biointerfaces2016147, 475-491
https://doi.org/10.1016/j.colsurfb.2016.08.027
                                              

30. Natural proline-rich cyclopolypeptides from marine organisms: Chemistry, synthetic methodologies and biological status
Wan-Yin Fang, Rajiv Dahiya, Hua-Li Qin, Rita Mourya, Sandeep Maharaj, Marine drugs2016, 14, 194
DOI:10.3390/md14110194
                                                   
29. Visible-light-mediated aerobic oxidative dimerizative annulation of β-carbonylketones: a facile strategy to construct highly functionalized furans
Zhen-Peng Shang, Gao-Feng Zha, Xiao-Qing Chen, Hua-Li Qin, Tetrahedron Letters201657, 4680-4683
https://doi.org/10.1016/j.tetlet.2016.09.008
                                             

28. Copper-mediated aerobic iodination and perfluoroalkylation of boronic acids with (CF3) 2CFI at room temperature
Xi-Hai Liu, Jing Leng, Su-Jiao Jia, Jian-Hong Hao, Fanglin Zhang, Hua-Li Qin, Cheng-Pan Zhang, Journal of Fluorine Chemistry2016,189, 59-67
https://doi.org/10.1016/j.jfluchem.2016.07.021
                              
27. Biological evaluation of synthetic α, β-unsaturated carbonyl based cyclohexanone derivatives as neuroprotective novel inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation
Gao-Feng Zha, Cheng-Pan Zhang, Hua-Li Qin, Ibrahim Jantan, Muhammad Sher, Muhammad Wahab Amjad, Muhammad Ajaz Hussain, Zahid Hussain, Syed Nasir Abbas Bukhari, Bioorganic & medicinal chemistry2016, 24, 2352-2359
https://doi.org/10.1016/j.bmc.2016.04.015

                                                  

26. Palladium-Catalyzed Arylation of Arylboronic Acids with Yagupolskii–Umemoto Reagents
Shi-Meng Wang, Xiao-Yan Wang, Hua-Li Qin, Cheng-Pan Zhang , Chemistry-A European Journal2016, 22, 6542-6546
DOI: 10.1002/chem.201600991

                                                

25. Synthesis of α, β-unsaturated carbonyl-based compounds, oxime and oxime ether analogs as potential anticancer agents for overcoming cancer multidrug resistance by modulation of efflux pumps in tumor cells
Hua-Li Qin, Jing Leng, Cheng-Pan Zhang, Ibrahim Jantan, Muhammad Wahab Amjad, Muhammad Sher, Muhammad Naeem-ul-Hassan, Muhammad Ajaz Hussain, Syed Nasir Abbas Bukhari , Journal of medicinal chemistry2016, 59, 3549-3561
DOI: 10.1021/acs.jmedchem.6b00276
           

24. A Metal-Free Diverse Synthesis of Difluoromethylthioethers and Difluorobis (arylthio) methanes from RSX (X= SR, Cl, SO2Ph) and TMSCF2H
Jia-Bin Han, Hua-Li Qin, Su-Hong Ye, Lei Zhu, Cheng-Pan Zhang , The Journal of organic chemistry201681, 2506-2512
DOI: 10.1021/acs.joc.6b00089
                      
23. Palladium-catalyzed Mizoroki–Heck-type reactions of [Ph2SR fn][OTf] with alkenes at room temperature
Shi-Meng Wang, Hai-Xia Song, Xiao-Yan Wang, Nan Liu, Hua-Li Qin, Cheng-Pan Zhang, Chemical Communications201652, 11893-11896
DOI: 10.1039/C6CC06089G
                                                

22. Pd-catalyzed divergent trifluoroethylation and arylation of arylboronic acids by aryl (2, 2, 2-trifluoroethyl) iodonium triflates
Jing Yang, Qiu-Yan Han, Cheng-Long Zhao, Tao Dong, Zhi-Yuan Hou, Hua-Li Qin, Cheng-Pan Zhang, Organic & biomolecular chemistry2016, 14, 7654-7658
DOI: 10.1039/C6OB01384H
                           
                                                    

21. Silver-mediated direct trifluoromethoxylation of α-diazo esters via the− OCF3 anion
Gao-Feng Zha, Jia-Bin Han, Xiao-Qian Hu, Hua-Li Qin, Wan-Yin Fang, Cheng-Pan Zhang, Chemical Communications, 201652, 7458-7461
DOI: 10.1039/C6CC03040H
                              
20. Ruthenium-catalyzed direct arylations with aryl chlorides
Gao-Feng Zha, Hua-Li Qin, Eric Assen B Kantchev, RSC Advances, 20166, 30875-30885
DOI: 10.1039/C6RA02742C
                                           

2015


19. A solvent-free facile synthesis of (E)-bis (phosphonium) ethylenes from organo-phosphines and TfOCH2 CF2H reagent
Shi-Meng Wang, Jia-Bin Han, Cheng-Pan Zhang, Hua-Li Qin, Tetrahedron Letters, 2015, 56, 6219-6222
https://doi.org/10.1016/j.tetlet.2015.09.092
                                     

18. An overview of reductive trifluoromethylation reactions using electrophilic ‘+ CF3’reagents
Shi-Meng Wang, Jia-Bin Han, Cheng-Pan Zhang, Hua-Li Qin, Ji-Chang Xiao, Tetrahedron2015, 71, 7949
DOI: dx.doi.org/10.1016/j.tet.2015.06.056
                                     


17. Recent Progress in Metal-Mediated Trifluoroethylation
Jia-Bin Han, Jian-Hong Hao, Cheng-Pan Zhang, Hua-Li Qin, Current Organic Chemistry, 2015, 19, 1554-1565
DOI: 10.2174/1385272819666150122235905
    

16. The Challenge of Linear (E)‐Enones in the Rh‐Catalyzed, Asymmetric 1, 4‐Addition Reaction of Phenylboronic Acid: A DFT Computational Analysis
Hua-Li Qin, Xiao-Qing Chen, Zhen-Peng Shang, Eric Assen B Kantchev, Chemistry-A European Journal, 201521, 3079-3086
DOI: 10.1002/chem.201405189
                                              

15. Computational modelling of the enantioselectivity in the asymmetric 1, 4-addition of phenylboronic acid to a bulky, doubly pro-chiral maleimide catalyzed by a Rh/chiral diene complex
Hua-Li Qin, Zhen-Peng Shang, Kaicheng Zhu, You-Gui Li, Eric Assen B Kantchev, RSC Advances20155, 74541-74547
DOI: 10.1039/C5RA12792K
                                                  

14. Molecular docking studies and biological evaluation of chalcone based pyrazolines as tyrosinase inhibitors and potential anticancer agents
Hua-Li Qin, Zhen-Peng Shang, Ibrahim Jantan, Oya Unsal Tan, Muhammad Ajaz Hussain, Muhammad Sher, Syed Nasir Abbas Bukhari, RSC Advances, 20155, 46330-46338
DOI: 10.1039/C5RA02995C
                                              

13. Transmetalation from B to Rh in the course of the catalytic asymmetric 1, 4-addition reaction of phenylboronic acid to enones: a computational comparison of diphosphane and diene ligands
You-Gui Li, Gang He, Hua-Li Qin, Eric Assen B Kantchev, Dalton Transactions201544 , 2737-2746
DOI: 10.1039/C4DT03147D 
                                   

12. Diversified facile synthesis of benzimidazoles, quinazolin-4 (3 H)-ones and 1, 4-benzodiazepine-2, 5-diones via palladium-catalyzed transfer hydrogenation/condensation cascade of nitro arenes unde
Kaicheng Zhu, Jian-Hong Hao, Cheng-Pan Zhang, Jiajun Zhang, Yiqing Feng, Hua-Li Qin, RSC Advances20155, 11132-11135
DOI: 10.1039/C4RA15765F
                                                
11. Computational modelling of the enantioselectivity in the asymmetric 1, 4-addition reaction catalyzed by a Rh complex of a S-chiral disulfoxide
You-Gui Li, Li Li, Ming-Yue Yang, Hua-Li Qin, Eric Assen B Kantchev, RSC Advances20155, 5250-5255
DOI: 10.1039/C4RA13012J 
                              

2014


10. A First‐Principles Examination of the Asymmetric Induction Model in the Binap/RhI‐Catalysed 1, 4‐Addition of Phenylboronic Acid to Cyclic Enones by Density Functional Theory Calculations
Hua-Li Qin, Xiao-Qing Chen, Yi-Zhen Huang, Eric Assen B Kantchev, Chemistry-A European Journal, 2014, 20, 12982-12987
DOI: 10.1002/chem.201402451
                                                     

9. Biological activity and molecular docking studies of curcumin-related α, β-unsaturated carbonyl-based synthetic compounds as anticancer agents and mushroom tyrosinase inhibitors
Syed Nasir Abbas Bukhari, Ibrahim Jantan, Oya Unsal Tan, Muhammad Sher, M Naeem-Ul-Hassan, Hua-Li Qin, Journal of Agricultural and Food Chemistry2014, 62, 5538-5547
DOI: 10.1021/jf501145b
                             

8. TfOH-catalyzed synthesis of 3-aryl isoindolinones via a tandem reaction
Jiaxing Hu, Hua-Li Qin, Wengang Xu, Junli Li, Fanglin Zhang, Hua Zheng, Chemical Communications201450 ,15780-15783
DOI: 10.1039/C4CC06653G
               

7. Computational and experimental comparison of diphosphane and diene ligands in the Rh-catalysed carboxylation of organoboron compounds with CO2
Hua-Li Qin, Jia-Bin Han, Jian-Hong Hao, Eric Assen B Kantchev, Green Chemistry2014, 16 , 3224-3229
DOI: 10.1039/C4GC00243A
                                           

Before WHUT

6. Synthesis of Geldanamycin
Hua-Li Qin and James S. Panek, Synfacts, 2008, 12, 1248-1248
DOI: 10.1055/s-0028-1087290

                                                       

5. Total Synthesis of Hsp90 Inhibitor Geldanamycin

Hua-Li Qin and James S. Panek, Organic letters, 2008, 10, 2477–2479.
DOI: 10.1021/ol800749w
                              

4. Mild Reductive Opening of Aryl Pyranosides Promoted by Scandium(III) Triflate  
Hua-Li Qin, Jason T. Lowe, and James S. Panek, J. Am. Chem. Soc. 2007, 129, 38-39.
DOI: 10.1021/ja067234o

                               
                        
3. 
Reaction of 1,3-Dicarbonyl Compounds with o-Phenylenediamine or 3,3- Diaminobenzidine in Water or under Solvent-free Conditions via Microwave
Irradiation

Zhong-Xia Wang and Hua-Li Qin, Journal of heterocyclic chemistry2005, 42, 1001
DOI: 10.1002/jhet.5570420540


2. Solventless syntheses of pyrazole derivatives 
Zhong-Xia Wang and Hua-Li Qin, Green Chemistry, 2004, 6, 90-92
http://dx.doi.org/10.1039/B312833D
                            
1. Regioselective synthesis of 1,2,3-triazole derivatives via 1,3-dipolar cycloaddition   reactions in water  
Zhong-Xia Wang and Hua-Li Qin, Chemical Communications2003, 2450-2451.
http://dx.doi.org/10.1039/B307084K